Bhagwan Das Bang, MD

The sharply demarcated, smooth red plaques on this 3-year-old's tongue had been present for several months. The child initially refused to stick out his tongue. He cooperated after he was offered a lollipop (with the stipulation that "the wider he opened his mouth, the bigger the lollipop he would receive").

For about a week, a 4-year-old girl had a nonpruritic rash that initially appeared on her legs and arms. Lesions then spread to her face, hands, and buttocks; the trunk was spared. About 2 weeks earlier, the child had had a viral illness that lasted a few days; since then she had been healthy.

A 13-year-old girl noticed that the skin around a "mole" on her abdomen had gradually changed color. This patient was told that she had a halo nevus--a pigmented (nevocellular) nevus surrounded by a tight ring of depigmentation--which is benign and usually regresses spontaneously over time. This relatively common lesion is believed to affect males and females equally. The development of the halo may coincide with puberty or pregnancy. Often, several pigmented nevi develop a halo simultaneously.

A 3-month-old infant was brought for evaluation after the sudden development of a tonic-clonic seizure that involved the left upper extremity. He had no history of fever, trauma, rash, refusal to suck, vomiting, diarrhea, upper respiratory tract infection symptoms, or bleeding. He was not taking any medications.

During a routine physical examination, a 3-year-old boy was noted to have speech delay and hyperactive behavior. The child was born at term to a 25-year-old mother with epilepsy, which was managed with phenytoin. His birth weight was 3.5 kg (7.8 lb); he had no neonatal problems or features of fetal Dilantin syndrome. However, he had undergone bilateral hydrocele and inguinal hernia repair and tube placement for recurrent ear infections. His half sister (from his mother's previous marriage) needs help in reading and math. His father is healthy.

The lashes on this 12-year-old girl's right eye are white and gray; the lashes on the left eye are black. This small patch of white-gray hair, known as poliosis, occurs most often along the forehead (the so-called white forelock); however, hair anywhere on the body can be affected. The appearance in healthy persons simply indicates a lack of pigment in the hair and skin of the involved area.

The parents of a 2-month-old infant were concerned about a gradually enlarging reddish mass in the inner canthus of their daughter's left eye. The 3-cm mass had been present for several weeks. It became engorged when the child cried or strained.

A 3-year-old boy presented with a pruritic perianal rash, rectal pain, and constipation of 3 weeks' duration. The child had initially been treated for pinworms by one of his caregivers.

After spending a day at the beach, a 12-year-old boy presented with a second-degree sunburn and blisters on his shoulders (A). According to his mother, he had used sunscreen. The child was not taking any medications. Except for a significant number of moles, his skin was normal.

During a routine annual checkup, a 5-ft 8-in, 94.5-kg (210-lb) 13-year-old girl was noted to have a hyperpigmented "dirty" lesion on the back of her neck. The girl's parents were also obese. Her mother had type 2 diabetes mellitus.

This 5-year-old girl with multiple congenital abnormalities presented for a routine checkup. She was born with Apert syndrome, also known as acrocephalosyndactyly.A peaked head, sloping eyes, and "mitten hands" are typical features.