Infectious Diseases

Based on reports by NoroSTAT-participating states, the total number of outbreaks in 2024-2025 seasonal year is above the range reported 012–2020 and 2021-2024 seasonal years.

The study within a single health care system revealed that most infants born prior to December received the nirsevimab monoclonal antibody.

This week the panel weighs in on monoclonal antibodies in this patient population as well as important overall takeaways about COVID-19 therapies.

From new topical dermatology treatments for atopic dermatitis to the first nasal spray to treat type 1 allergic reactions, these are our top FDA approvals of 2024.

The federal agency has set a target action date of June 10, 2025 for potential approval.

Early HPV vaccination at age 9 boosts completion rates, reduces disparities, and enhances cancer prevention effort, according to a recent study from Nemours Children's Health.

The halt follows a severe respiratory disease safety signal observed in a July 2024 phase 1 trial of Moderna's mRNA-1345 and mRNA-1365 vaccine candidates.

Editor-in-chief Tina Tan, MD, FAAP, FIDSA, FPIDS, highlights the final Contemporary Pediatrics journal of the year.

Zelicapavir demonstrated a favorable safety profile and was well-tolerated. The N-protein inhibitor has been granted Fast Track Designation by the FDA.

The most common reactions reported were the following: irritability or fussiness (30.1%), local reactions (21.1%) and fever (13.8%).

Reportedly, the child experienced mild symptoms and has received flu antivirals.

From 2017-2018, antiviral treatment of hospitalized children with influenza ranged from 70%-86%. In the 2023-2024 season, it was less than 60%.

A further understanding of the role SARS-CoV-2 plays in T2D incidence can add an important component to benefit and risk considerations to prevent COVID-19.

The initiation of a phase 2 study of the investigational 31-valent pneumococcal conjugate vaccine is expected by the end of January 2025.

The study outcomes were estimated IMD cases and deaths averted by MenACWY vaccination in adolescents and adults aged 11 to 23 years.

Severe outcomes among children with pneumonia were uncommon, regardless of whether antibiotics were received based on study results.

"The novel RSV prevention strategies may reduce ICU morbidity and mortality for children," the study authors concluded.

Look back at several quick video interviews discussing the expanding role of artificial intelligence, how RSV treatment has evolved, and much more.

Donna Hallas, PPCNP-BC, CPNP, PMHS, FAANP, FAAN, highlights key takeaways from our October Vaccine issue of Contemporary Pediatrics.

HPV vaccination in Brazil led to significant reductions in genital warts and cervical precancer hospitalizations, especially among those under 20 years of age.

Panama’s switch to the 9-valent HPV vaccine promises greater protection and reduced cancer rates, preventing thousands of HPV-related cases and deaths.

There were no treatment or RSV-related deaths during the study.

Overall, 2 doses of TAK-003 successfully induced the production of neutralizing antibodies against all 4 dengue serotypes in at least 90% of adults, children, and adolescents, regardless of whether they were seronegative or seropositive at baseline.

Trivalent seasonal influenza vaccines include 2 influenza A viruses (H1N1) and 1 influenza B virus.

A single dose of the mRNA-1273.222 vaccine demonstrated strong immune responses against various omicron subvariants and showed a favorable safety profile compared to existing vaccines.

Rana Hamdy, MD, discussed her session at the 2024 AAP meeting, highlighting treatment duration with antibiotics for community-acquired pneumonia as well as the importance of understanding amoxicillin allergy.

A look into CDC numbers for increasing pertussis cases in the United States, along with commentary from our editor-in-chief, Tina Tan, MD, FAAP, FIDSA, FPIDS.

At AAP 2024, Rana Hamdy, MD, shared insights from her session, "Diagnosis and Treatment of Community-Acquired Pneumonia."

Our editor-in-chief Tina Tan, MD, FAAP, FIDSA, FPIDS, previews some of the American Academy of Pediatrics National Conference & Exhibition, taking place right now in Orlando, Florida.

With this approval, FluMist becomes the first vaccine to prevent influenza that does not need to be administered by a health care provider.