Joshua Fitch, Senior Editor

Patients 6 years and up with ADHD now have alternate options for prescription lisdexamfetamine dimesylate (Vyvanse; Takeda Pharmaceuticals USA Inc), after the FDA-approval of multiple generic options.

Rob Knight, PhD, Wolfe Endowed Chair in Microbiome Science at Rady Children's Hospital-San Diego, professor of pediatrics, UCSD, explains how links between gut microbiomes and cognitive and neurological conditions are being researched and what could be ahead for these associations in children.

Review some of the top stories from the Contemporary Pediatrics website over the last week, and catch up on anything you may have missed.

Across a variety of concerns, the overuse of devices and screen time was the top concern for parents listed in the 2023 Top 10 Child Health Concerns for Parents, released by the C.S. Mott Children’s Hospital National poll on Children’s Health.

Investigators of a study published in Pediatrics examined whether a 30-minute exposure to outdoor air (< 50 °F) would improve symptoms of mild to moderate croup.

In 2021, firearm deaths continued to be the leading cause of death for US children, with further worsening disparities noticed, according to a study published in Pediatrics.

Study authors concluded that developmental delay domains should be separately considered when discussing screen time and potential delays in childhood development.

In this Contemporary Pediatrics® interview, Tammy Brady, MD, PhD, explains how an incorrectly-fitting blood pressure cuff can lead to the wrong diagnosis in the pediatric population, and what tips to look for when shopping for cuffs currently on the market.

Tina Tan, MD, FAAP, FIDSA, FPIDS, discusses what Pfizer's recently FDA-approved RSV vaccine means for infants ahead of the traditional RSV season.

Approved for use at 32 weeks through 36 weeks gestation, Pfizer’s maternal respiratory syncytial vaccine (Abrysvo), is delivered through a single dose injection to the muscle, and is the first vaccine for use in pregnant individuals to prevent lower respiratory tract disease (LRTD) and severe LRTD because of RSV in infants (birth to 6 months).

Review some of the top stories from the Contemporary Pediatrics website over the last week, and catch up on anything you may have missed.

Regeneron states all 10 patients achieved normalization of serum albumin and serum IgG concentrations by week 12 in a phase 2/3 trial that investigated the safety and efficacy of pozelimab-bbfg. These concentrations were maintained through 72 weeks.

Children followed up with at 5 years of age that were exposed to the COVID-19 pandemic were 4.39 months behind in overall childhood development, whereas children followed up with at 3 years of age demonstrated positive associations.

Palovarotene is now the first and only treatment for the ultra-rare bone disease fibrodysplasia ossificans progressive (FOP), which impacts approximately 400 people in the United States and 900 globally.

Watch as Rob Knight, PhD, Wolfe Endowed Chair in Microbiome Science at Rady Children's Hospital-San Diego, professor of pediatrics, UCSD, talks the gut microbiome and the potential associations with cognitive and neurological conditions in children, and why the topic is gaining interest and momentum.

Investigators concluded that clinicians should be aware, for individuals with a prior rotavirus-associated hospitalization, of an elevated susceptibility to autoimmune disease in these patients. 

The recommendation from the American Academy of Pediatrics (AAP) follows the unanimous recommendation by the CDC advisory group for routine use of nirsevimab in newborns and infants younger than 8 months born into or entering their first RSV season.

Share this link with your patients' parents so they can review the latest back-to-school tips for them and their child as the fall approaches.

Basis for a Biologics License Application submission to the FDA is being built for PXVX0317, following topline results demonstrated in a pair of phase 3 trials, including 1 trial featuring adolescents and adults aged 12 to 64 years.

Study authors stated that several past studies have put focus on training an independent model separately for lung or heart sound diagnosis but note that having a model that can “simultaneously detect abnormal lung and heart sounds,” is essential.

Results of the randomized, multi-site study demonstrated the importance of early diabetes detection, as a single episode of diabetic ketoacidosis (DKA) in young children with type 1 diabetes was associated with lower IQ scores soon after exposure.

The resubmission, which included new long-term follow-up data and a post-hoc propensity match study, was issued a complete response letter by the federal agency, which requires “more data to support marketing approval,” according to a press release from Mesoblast Limited.

Jeanne Franzone, MD, orthopedic surgeon, surgical director, Osteogenesis Imperfecta Clinic, co-director, Prosthesis Clinic, Nemours Children’s Health, Delaware Valley, discusses recent technology, recommendations, and interactions with general health care providers in this Contemporary Pediatrics® interview.

To combat this association, study investigators concluded a reduction in daily soft drink consumption should be a priority among school-going adolescents.

In this Contemporary Pediatrics® interview, Samir Gautam, MD, (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, senior author of a recently published study in the Journal of Allergy and Clinical Immunology: In Practice, reviews key findings of the study and explains how they relate to the pediatric population. Watch the full interview below.

The ACIP voted in unanimous fashion, 10 to 0, to recommend routine use of nirsevimab-alip for newborns and infants younger than 8 months, born during or entering the first RSV season according to a press release from Sanofi.

Previously available under an Emergency Use Authorization, the combination test can detect and distinguish COVID-19, influenza A/B, and respiratory syncytial virus (RSV). The clearance comes ahead of respiratory season, which, according to BD, could result in another “tripledemic” threat.

In a letter addressed to the public, the FDA and Drug Enforcement Agency stated that prescription stimulant drug shortages are impacting patients and their families The agencies are taking a multifaceted approach to mitigate these shortages and find potential solutions.

Updated guidance for pediatricians that interact with children and their families, who need a potentially life-saving organ donation or transplantation, has been released by the American Academy of Pediatrics (AAP).

In this review article, take a look back at the top-performing stories from Contemporary Pediatrics from April to August 2023. With each article highlighted below, you’ll find updated news and notes along with a quick recap and direct link to our most-viewed articles.