Joshua Fitch, Senior Editor

Results from a pivotal phase 2 clinical trial revealed axatilimab met the primary outcome in all cohorts for graft versus host disease (GVHD) in pediatric and adult patients. Based on its safety and efficacy profile demonstrated in clinical trials, Syndax and Incyte intend to file a biologics license application (BLA) for axatilimab with the FDA by the end of 2023.

Results from this active, facility-based surveillance study revealed hospitalization rates for children younger than 5 years were 1.7 to 7.1 times higher among American Indian and Alaska Native children compared to estimates from the methodologically similar US New Vaccine Surveillance Network (NVSN).

Following the resubmission of a new drug application, the FDA has approved VP-102 to treat molluscum contagiosum, a contagious skin disease transmitted through direct skin-to-skin contact that primarily affects children.

According to Pfizer, the investigational vaccine to protect against Group B Streptococcus (GBS) generated maternal antibody responses against 6 capsular polysaccharide serotypes and efficiently transferred antibodies to the infants. The announcement of this phase 2 data comes in July, which is International Group B Streptococcus Month.

Lorazepam, diazepam, midazolam, fentanyl, hydromorphone, morphine, ketorolac, epinephrine, diphenhydramine, and methylprednisolone were investigated in the study. Overall, the most common type of deviation was an underdose.

Overall, results from the report demonstrated that cannabis-involved emergency department (ED) visits for individuals under 25 years increased during the pandemic. For those aged 10 years or younger, the weekly number of cannabis-involved ED visits during the pandemic far exceeded the number of visits observed prepandemic.

Using 3 complementary statistical approaches of linear modeling, Bayesian, and multigroup factor analysis, investigators determined IQ scores are not negatively impacted by pediatric concussion up to 3 months postinjury.

John Bradley, MD, medical director, infectious disease, Rady Children's Hospital, San Diego, California; professor of pediatrics, UC San Diego School of Medicine, explains how recently FDA-approved nirsevimab-alip will impact the newborn and infant RSV patient population.

According to the report, 34% of parents are using patient portals for advice regarding their child’s illness.

The approval follows a unanimous vote of support from the FDA Antimicrobial Drugs Advisory Committee of nirsevimab-alip’s favorable benefit-risk profile for the prevention of Respiratory Syncytial Virus (RSV) lower respiratory tract disease (LRTD) in newborns and infants amid their first RSV season.

The FDA has identified NOxBOX Ltd’s recall of NOxBOXi Nitric Oxide Delivery System as a Class I recall. Affected devices to the newborn and neonate patient populations can cause nitric oxide therapy interruptions because of a check valve misalignment. As of July 13, 2023, no injuries or deaths have been reported according to the federal agency.

To better protect children from its several negative effects, the Environmental Protection Agency (EPA) has proposed stricter requirements for lead-based paints in pre-1978 buildings and childcare facilities.

Despite several health and nutrition claims on breast milk substitutes and infant formula products, little to no evidence supported these claims in a multicountry study published in BMJ.

To increase access and further support healthy meals in schools across the nation, the US Department of Agriculture has dedicated millions of dollars in grants to achieve this goal.

Deep learning models have the potential to assist clinicians in determining suspicion for abusive head trauma (AHT) by screening pediatric head computed tomography (CT) images for retinal hemorrhage, according to a recent study.

Study investigators found that children with posttraumatic migraine symptoms after a concussion had higher symptom burden and lower quality of life 3 months after the injury compared to those with nonmigraine headache.

Sandra H. Jee, MD, MPH, professor of pediatrics, director, Center for Community Health and Prevention, Finger Lakes Children’s Environmental Health Center, University of Rochester Medical Center, addresses how health care institutions contribute to the climate crisis. In this Contemporary Pediatrics® interview, Jee provides practical examples health care professionals can use in their offices to better help the environment, which can better help patients in the long term.

To combat instances of e-liquid exposure and accidental ingestions among children, the FDA is offering tips for best storage and safety practices for those that regularly use and handle these products, according to a recent press release.

Improvement in the left ventricular ejection fraction (LVEF) and statistically significant benefit in the Performance of the Upper Limb (PUL v2.0) scale were observed following 2 years of CAP-1002 treatment in Duchenne muscular dystrophy (DMD) patients.

According to Italfarmaco Group, a New Drug Application (NDA) for givinostat has been accepted and granted priority review by the FDA to treat Duchenne muscular dystrophy (DMD) patients, following positive topline phase 3 trial results.

Indicated for growth hormone deficiency (GHD) patients aged 3 years and older, somatrogon-ghla is now FDA-approved to treat GHD following positive phase 3 data demonstrating non-inferiority, measured by annual height velocity at 12 months, compared to somatropin.

Nicole Peña Sahdala, MD, internist, gastroenterologist specialist in bariatric endoscopy, ABIM certified, discusses the rise in bariatric surgery among youth, and why other forms of care, such as lifestyle changes and education, are essential before any surgery is performed.

About 1 in 4 children are exposed to intimate partner violence (IPV) in their lifetime, according to the American Academy of Pediatrics. The AAP has released tips and recommendations for pediatricians to help support these patients and their families.

After Owlet’s baby-monitoring Smart Sock was pulled from the market in 2021, the FDA has cleared the company’s BabySat pulse oximetry sock for infants, capable of monitoring and alerting parents of pulse rate and oxygen saturation levels.

After receiving accelerated approval, delandistrogene moxeparvovec-rokl is the first gene therapy to treat Duchenne muscular dystrophy (DMD) in ambulatory pediatric patients aged 4 to 5 years.

In this Contemporary Pediatrics® interview, Dave Little, MD, MS, Physician Informaticist at Epic, discusses the importance of lipid screening in the pediatric population, specifically for children aged 9 to 11 years and those aged 2 to 8 years with increased risk of diabetes, obesity, or high blood pressure. Little says awareness of lipid screenings at the provider and parent levels can lead to more screenings overall, which can lead to healthier lifestyles for children.

Children 10 years and older with type 2 diabetes (T2D) can now be treated with empagliflozin and empagliflozin plus metformin hydrochloride to improve blood sugar control, per a recent approval by the FDA.

Links between teenager anxiety and gastrointestinal (GI) issues are the subject of this Contemporary Pediatrics® interview with Julia Anderson, MD, MSCI; and Sara Francis, PhD.

A family-centered procedural sedation protocol for children with autism spectrum disorder (ASD) or developmental delay (DD) allowed 93% of patients to be free of restraints during routine health care procedures.

Based on results from a recent C.S. Mott Children’s Hospital National Poll on Children’s Health, find out how comfortable parents feel when it comes to abdominal pain in their child, and how likely they are to handle the issue themselves, or to reach out to a health care provider for help.