Marian Freedman

"Less pain and no need for sedation are major benefits," said Jon Matthew Farber, MD, in this edition of Journal Club.

"I’m all for reducing opioids, especially in neonates, for whom we are unsure of long-term adverse effects," stated Jon Matthew Farber, MD.

"My takeaway is that if medicine is needed, stimulants will be my first choice in this age group, regardless of whether the ADHD coexists with ASD."

"Many of my patients with poorly controlled seizures have tried cannabidiols. Unfortunately, they have not been effective in these nonsyndromic epilepsies," said Jon Matthew Farber, MD.

Parents had a variety of preferences and motivations for acquiring prognostic genetic information about their child, but 4 major findings emerged from parental interviews. Click to read more.

Daily intervention intensity was not associated with significant effect sizes for any of the 4 intervention types, though technology-based interventions showed the largest positive association.

"The quest for a cure for colic continues," noted Jon Matthew Farber, MD.

"This is another example of how people trying to find a useful therapeutic role for magnesium usually come up short," stated Jon Matthew Farber, MD.

"Bottom line: It should be safe (there is a potential for freeze burns if misapplied), so patients are welcome to try it," said Jon Matthew Farber, MD.

Dressing changes are less painful for neonates and minimize the risk of bleeding or oozing. In addition, complete wound coverage with the dressing helps prevent dehydration and heat loss.

Jon Matthew Farber, MD, offers quick thoughts on a recent study regarding bone health and activity among adolescents withJIA.

The most common comorbid conditions were endocrinopathies (10%), trisomy 21(5%), and attention-deficit/hyperactivity disorder (4%).

When it comes to easing pain from a needlestick, pairing a dog with the human administering the needlestick was more successful than the human alone, according to results of a study conducted in a hematology oncology clinic.

"Parents still ask about this. Indeed, many years ago the FDA approved a prescription form of a PUFA, Vayarin, for the treatment of patients with ADHD. It is no longer available, so I assume it did not work. There may be good reasons for taking a PUFA supplement, but having ADHD is not one of them." -Jon Matthew Farber, MD

"Obesity and treatment with growth hormone in children with PWS are known risk factors for hypoventilation as well as OSAS."- Jon Matthew Farber, MD

"I suspect that some doctors still have not changed their ways, so if you see your ENT, EM, or pediatric colleagues prescribing them, please ask them to stop." - Jon Matthew Farber, MD.

Investigators therefore concluded that ROAR provides an excellent way to identify children at highest risk of having poor reading skills.

The tool, the Kaiser Permanente neonatal EOS calculator, is designed to guide decision making based on objective data available at birth.

Approximately half of study participants had tried lifestyle modifications and used vitamin supplementation, and most were taking multiple medications.

The analysis was based on 573 hospitalizations (most patients had an average of 2 hospitalization episodes) in which new BCs were drawn more than 48 hours after initial cultures were negative.

Compared with controls, children with CHD performed less well across all WISC-V indices and with large effect sizes for all indices and most subtests.

The authors indicate that delays in diagnosis of endometriosis can lead to disease progression and an impact on fertility, whereas early diagnosis and appropriate management may result in less major surgery in adulthood.

Investigators developed an algorithm indicating that only 7.7% of patients with BHS require an ECG at BHS diagnosis, a much lower proportion than the 45.1% of those who had undergone the test in the study sample.

The 2 groups did not differ in how likely they were to fill at least 1 prescription of any antibiotic while enrolled in kindergarten.

Smartphone applications to estimate bilirubin levels correlate reasonably well with serum bilirubin levels, according to a meta-analysis of 14 studies.

The study evaluated whether fetuses with Down syndrome and normal obstetric ultrasounds (OB-USs) had missed diagnoses of critical congenital heart disease (CHD) by conducting a retrospective review.

Investigators asked the children’s parents about the history of musculoskeletal-related disease, observed the children’s gait, and performed physical examinations.

A systematic review and meta-analysis found that such sequencing indeed has an equivalent high genetic diagnostic yield in cerebral palsy, which supports including this neurodevelopmental disorder among those for which diagnostic exome sequencing should be used.

To assess the role of familial factors, investigators analyzed data for a family-based group created from another Swedish national register that included 833,172 individuals without ADHD with different levels of relatedness to the individuals with ADHD and a group of matched controls.

The 20 children in the investigation had been diagnosed with ASD by PCPs who were trained using the ECHO (Extension for Community Healthcare Outcomes) Autism Screening Tool for Autism in Toddlers and Young Children (STAT).