"Many of my patients with poorly controlled seizures have tried cannabidiols. Unfortunately, they have not been effective in these nonsyndromic epilepsies," said Jon Matthew Farber, MD.
The study authors noted that without video evidence, seizures would not have been implicated in death investigations and that seizure-related deaths are underrecognized in patients with epilepsy and in those without.
The reaction, called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), can start as a rash but can progress quickly, potentially resulting in injury to internal organs, hospitalization, and death.
While treatment discontinuation because of adverse events was more likely when taking dietary therapies for treating childhood drug-resistant epilepsy, reduction of seizures and seizure freedom were significantly more common.
Elia Pestana Knight, MD; and Whitney Mitchell discuss how CDKL5 deficiency disorder affects children, and how ganaxolone (ZTALMY; Marinus) can drastically improve and even save lives.