April 18th 2025
The sBLA for dupilumab (Dupixent) was supported by data from the phase 3 LIBERTY-CUPID clinical program in patients with uncontrolled CSU.
A Tethered Approach to Type 2 Diabetes Care – Connecting Insulin Regimens with Digital Technology
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Surv.AI Says™: What Clinicians and Patients Are Saying About Glucose Management in the Technology Age
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Addressing Healthcare Inequities: Tailoring Cancer Screening Plans to Address Inequities in Care
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Cases and Conversations™: Applying Best Practices to Prevent Shingles in Your Practice
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Identifying Sleep-Related Problems in Teens
February 1st 2009Sleep is an important, yet frequently underestimated component of adolescent health. Adequate sleep is essential for achieving maximal cognitive abilities as well as for maintaining the energy needed to meet the demands of a busy adolescent’s schedule. Lack of quality sleep can result in attention problems, cognitive dulling, various somatic complaints (such as headaches and abdominal pain), and mood disturbances.
Atypical Kawasaki Disease and Hepatosplenomegaly
January 3rd 2009A 4-month-old boy was transferred to our center from a community care hospital because of persistent fever (temperature up to 39.4°C [103°F]) of 5 days’ duration. He also had decreased activity, increased irritability, occasional vomiting after feedings, and a few episodes of loose stool.
Evidence of Benefits of Allergy Assessment in Patients With Asthma
December 1st 2008The most common chronic medical problem that we pediatricians treat is asthma. We do our best to manage our patients' asthma by prescribing controller medications, providing asthma action plans, and guiding families through acute exacerbations. We often ask about possible environmental triggers, such as tobacco smoke and cockroaches, and we advise patients to reduce their exposure to those triggers.
Childhood Obesity, Part 1: Weight Evaluation and Comorbidity Screening
December 1st 2008Measurement of body mass index (BMI) is an effective way to screen for obesity and is an important part of the routine health evaluation of all children. A fasting blood sugar test is recommended for obese children 10 years and older who have a BMI above the 85th percentile for their age and sex and 2 high-risk criteria for diabetes (eg, positive family history or signs of insulin resistance). Patients with a BMI at the 85th percentile or higher also require screening for other comorbidities. Such screening includes measurement of waist circumference, blood pressure, lipid levels (specifically, levels of high- and lowdensity lipoprotein cholesterol and triglycerides, as well as total cholesterol), and liver transaminase levels.
Teenaged Girl With Acute Chest Pain
December 1st 2008A previously healthy 15-year-old girl presents with right-sided chest pain that began a few hours earlier during Spanish class. The pain is nonradiating; it is alleviated by leaning forward and exacerbated by sitting still. Shortly after its onset, the patient had taken acetaminophen, which provided temporary relief. However, when she returned home from school, the pain resumed. She denies fever, shortness of breath, nausea, vomiting, and cough.
Hypopigmented Patches in Infant With a History of Seizures
December 1st 2008Four-month-old Hispanic boy brought for evaluation because of hypopigmented patches on his skin and a history of seizures. Infant was the product of an uncomplicated pregnancy; born at 40 weeks' gestation to a 16-year-old gravida 1, para 1 mother who received appropriate prenatal care. At birth, he had multiple hypopigmented patches on his face, torso, and extremities. At age 2 months, he was hospitalized for new-onset seizures.
Papular Perianal Rash in an 8-Year-Old Girl
November 1st 2008An 8-year-old girl is brought to the emergency department by her mother with a complaint of 5 days of worsening constipation and rectal bleeding. For the past week, the girl has had small stools 3 or 4 times a day and crampy abdominal pain. Yesterday, her stools were streaked with a small amount of blood. The mother notes that her daughter spends up to an hour in the bathroom with each bowel movement. In addition, the mother remarks that the girl has a rash in the rectal area and along the inner thighs.
Cystic Hygroma in an 11-Year-Old Girl
November 1st 2008An 11-year-old girl presented with a swelling on the left side of the chin of 1 month's duration; in the past 24 hours, following a bite by an unidentified insect, the swelling had rapidly enlarged and become painful (A). She was otherwise healthy and had no significant medical or family history.
Drug-Induced Urticaria in a 17-Year-Old Boy
October 1st 2008For 2 days, a 17-year-old boy had a widespread pruritic eruption that involved the trunk and extremities but spared most of the face. Many of the lesions were annular, and they would appear and resolve within 1 day. The patient denied shortness of breath, difficulty in swallowing, and periorbital swelling.
Risky Business, Part 2: Communicating Medical Risks to Patients and Parents
October 1st 2008Practicing pediatricians commonlytalk with patients and parentsabout medical risks. Examples of suchrisks include those of a newborn havinga genetic disease, of a complication of anillness developing, and of a patient experiencingan adverse effect from a medicationor vaccine. Different ways of expressingand communicating risk mayhelp patients and parents understand themagnitude of a risk and make informed,thoughtful decisions about their medicalcare. It is important to be aware of theinfluence personal experience and concernshave on how risk is perceived andto recognize how the choice of a particularway of framing a risk may inadvertentlycommunicate a clinician's personalbiases in a situation.
Another Potential Effect of Maternal SSRI Use on Newborns
October 1st 2008In the newborn nursery, pediatricians commonly encounter infants born to mothers who were receiving selective serotonin reuptake inhibitors (SSRIs) for depression during pregnancy. Earlier studies suggested a number of potential effects of maternal SSRI use on the newborn; these included jitteriness, agitation, diarrhea, hypoglycemia, vomiting, hypothermia, respiratory distress, seizures, feeding difficulties, increased or decreased tone, low birth weight, and small size for gestational age.1
Sacrococcygeal Pilonidal Sinus
October 1st 2008The cause was pilonidal sinus disease. The term pilonidal is derived from the Latin words "pilus," meaning "hair," and "nidus," meaning "nest." Pilonidal sinus disease is more common in males than in females and typically appears during adolescence. About 1% of all males and 0.1% of all females have an asymptomatic pilonidal sinus with potential for disease.1 The suspected overall incidence is about 1 in 5000. The disease seems to be most prevalent in those with stiff, dark or auburn hair, although it has been observed in all races.2
Blaschko Lines:Following "Lines of Evidence" to a Rash Diagnosis
September 1st 2008Many factors can be considered in attempting to establish the cause of a skin disorder. These include the color, morphology, and location of the lesions; associated symptoms, such as itching and fever; and exposure to drugs or to other children who have a rash. Linearity of the lesions may also suggest the diagnosis.