April 18th 2025
The sBLA for dupilumab (Dupixent) was supported by data from the phase 3 LIBERTY-CUPID clinical program in patients with uncontrolled CSU.
A Tethered Approach to Type 2 Diabetes Care – Connecting Insulin Regimens with Digital Technology
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Surv.AI Says™: What Clinicians and Patients Are Saying About Glucose Management in the Technology Age
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Addressing Healthcare Inequities: Tailoring Cancer Screening Plans to Address Inequities in Care
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Cases and Conversations™: Applying Best Practices to Prevent Shingles in Your Practice
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Tularemia in a 4-Year-Old Girl
During spring vacation, a previously healthy 4-year-old girl visited western Nebraska, where she and her family spent time along a river bank in a wooded area. After 4 days, her mother noticed 3 engorged ticks embedded in the child's scalp. The ticks were immediately removed and burned. The child also had a marble-sized swelling on the right side of her neck. Over the next few days, the child had temperatures that spiked to 39.4C (103F), with chills, generalized malaise, and weakness. There was no history of cough, myalgias, or headache.
Cutis Marmorata in a 6-Week-Old Boy
February 1st 2008This skin abnormality is cutis marmorata-a physiological dilatation of capillaries and venules of the trunk and extremities in infants and young children caused by exposure to cold. The discoloration fades with warming, as was the case with this baby. The condition is seen especially when subcutaneous fat is decreased.
Neonate With Hypotonia and Subtle Anomalies
February 1st 2008On morning rounds in the well-baby nursery, a nurse brings your attention to a 1-day-old girl who is having trouble latching onto the breast. You examine the child and note the subtle anomalies shown in Figure 1 along with a pronounced head lag and a systolic heart murmur.
Secondary Syphilis Palmar Lesions
February 1st 2008The patient denied use of new skin products, detergents, or medications. He had no pets. There was no history of recent travel, and the patient was not aware of any arthropod bites. None of his family members had a similar rash. The patient was sexually active and had had 3 partners in the past 2 years; he said he always used condoms. His history was otherwise unremarkable, as were physical findings.
Persistent swelling, red eruptions
January 1st 2008A 20-month-old is seen because of skin swelling and diffuse red eruptions that causes her to refuse to walk. Urticaria multiforme is diagnosed. Supportive treatment with oral antihistamines is prescribed. The child is walking and playing 24 hours later.
Peanut Allergy: Earlier Exposure--Earlier Reactions
January 1st 2008With the banning of peanut butter and jelly from some school cafeterias, peanut allergies have become a popular topic in the media and the public. Discussions often include references to an increasing prevalence of allergies, as well as to an earlier emergence of those allergies in children.
Pityriasis Lichenoides Et Varioliformis Acuta in a 10-Year-Old Boy
January 1st 2008A 10-year-old boy presented with a persistent rash that began several months earlier as recurrent crops of papules and a few vesicles with crusting. Varicella was initially diagnosed, and the patient was treated unsuccessfully with over-the-counter drying lotions. The patient denied systemic symptoms and pruritus and was in his usual state of health otherwise. Review of systems, family history, and social history were unremarkable. There was no history of travel or new exposures during this period.
Answer to Last Month’s Online Challenge
January 1st 2008Infantile seborrhea has many of the features of the other papulosquamous conditions listed, but the diagnosis is most commonly clinically evident on examination alone. If you are unsure, a KOH preparation will quickly sort out the dermatophytes. Also, the lack of itch makes atopic dermatitis very unlikely.
Trachyonychia (Twenty-Nail Dystrophy)
January 1st 2008I believe that there is an entity termed "twenty-nail dystrophy" that is a benign and idiopathic disorder. The nail plates have a distinct appearance and all 20 nails are dystrophic. The nail plates are lusterless and their surface appears to have been sandpapered in a longitudinal direction. The plates are thin and rough with accentuated longitudinal ridges and the cuticles appear to be "roughed up" and thickened. The free ends of the plates are brittle and rough. The nail plates do not appear to be growing.
Peanut Allergy: Earlier Exposure-Earlier Reactions
January 1st 2008With the banning of peanut butter and jelly from someschool cafeterias, peanut allergies have become a populartopic in the media and the public. Discussions ofteninclude references to an increasing prevalence ofallergies, as well as to an earlier emergence of thoseallergies in children.
Pityriasis Lichenoides Et Varioliformis Acuta (Mucha-Habermann Disease)
January 1st 2008Numerous scattered, mildly erythematous, brownish papules were scattered over the trunk, upper extremities, buttocks, and upper thighs. Many were slightly scaly and several had developed an eschar. The patient also had multiple areas of postinflammatory hyperpigmentation and a few varioliform scars. Other examination findings were normal.
Toddler Who "Caught Psoriasis" at Her Day-Care Center
December 1st 2007The parents of this 12-month-old girl are concerned that their daughter “caught” psoriasis at her day-care center. The rash had been present for at least 6 months, after which it cleared significantly, only to return weeks later. The child does not seem to be bothered by it.