April 18th 2025
The sBLA for dupilumab (Dupixent) was supported by data from the phase 3 LIBERTY-CUPID clinical program in patients with uncontrolled CSU.
A Tethered Approach to Type 2 Diabetes Care – Connecting Insulin Regimens with Digital Technology
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Surv.AI Says™: What Clinicians and Patients Are Saying About Glucose Management in the Technology Age
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Addressing Healthcare Inequities: Tailoring Cancer Screening Plans to Address Inequities in Care
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Cases and Conversations™: Applying Best Practices to Prevent Shingles in Your Practice
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Group A -Hemolytic Streptococcal Vulvovaginitis
July 1st 2007An otherwise healthy 3-year-old girl was brought for evaluation of fever, sore throat, and shaking chills of 12 hours' duration. She had beefy-red, posterior oropharyngeal erythema and a scarlatiniform rash on her shoulder that had been present for a few hours. The rash faded out over her chest but reappeared in the perineum and lower abdomen. She also had vulvovaginal inflammation with surrounding erythema. The mother was surprised to see the inflammation, but in retrospect added that the child had complained of vaginal discomfort as well. A rapid antigen test for group A b-hemolytic streptococci (GABHS) from a swab of the oropharynx was positive.
Indurated Lesion on Child's Metacarpophalangeal Joint
July 1st 2007A 6-year-old girl is brought for evaluation of an asymptomatic indurated erythematous lesion that erupted on the metacarpophalangeal joint of one hand 2 weeks ago. The patient has no history of trauma or exposure and is otherwise healthy.
Update on Pediatric Rheumatology
July 1st 2007ABSTRACT: Dramatic progress has been made in our understanding of pediatric rheumatic disease. Various classification systems help identify juvenile idiopathic arthritis (JIA), which involves unique considerations that distinguish it from rheumatoid arthritis in adults. Vaccination issues are important for children with JIA. Renal involvement with systemic lupus erythematosus (SLE) is more common and more severe in children than in adults, but treatment of children who have SLE is similar to that of adults. Neonatal lupus erythematosus may occur in infants whose mothers have SLE. Juvenile dermatomyositis is associated with significant morbidity and mortality. Kawasaki disease is a common vasculitis of childhood, especially in infants and toddlers. Each of at least 8 major familial periodic fever clinical syndromes has specific distinguishing characteristics.
Child With "Burns" on the Tongue
June 1st 2007A healthy 4-year-old girl presented to the emergency department (ED) with suspected inflicted burns on the tongue. Initially, the patient had complained of a burning mouth to school staff. On direct questioning by the principal, the child said her mother had burned her tongue with a cigarette. School staff noted the lesions.
Nummular Eczema and Juvenile Plantar Dermatosis
June 1st 2007For several weeks, this 21/2-year-old boy has had erythematous annular lesions on the lower trunk and proximal lower extremities. He was treated for pityriasis rosea only to have the lesions recur when the topical corticosteroid was discontinued.
Erythema Infectiosum and Acropustulosis of Infancy
April 1st 2007This young girl is brought to your office with a rash that her mother thinks is triggered by sunlight. The mother is concerned because her own aunt has lupus erythematosus. The mother also reports that several children at her daughter's school have a similar eruption.
Child With Bullous Lesion on Left Side of Groin
April 1st 2007A 16-month-old Hispanic girl presented with a 2-day history of pain, redness, and swelling of the left side of her groin. Her mother first noticed the lesion after the child was seen limping and scratching the area. The mother thought her child had been bitten by an insect but did not witness any bite.
Erythema Multiforme or Urticaria?
April 1st 2007In the February 2007 issue (Photo Quiz, page 88), there is a case of a child with a rash diagnosed as erythema multiforme (EM) rather than urticaria. I assume that these were fixed lesions, which distinguished them from urticaria lesions? Also, if this rash had been caused by the antibiotic the patient had been taking for an acute otitis media infection, why did it first manifest after 4 days of treatment?
Fever and cutaneous lesions in a 2-year-old toddler: More than skin deep?
March 1st 2007It is early evening when a previously healthy 2-year-old Hispanic girl is brought to the hospital by her mother. The girl has a history of fever to 100.2 F axillary, and skin lesions that began four days earlier. The skin lesions are described as following a progressive course. The lesions would begin as non-itchy red patches with a central vesicle that would burst, leaving an ulcer with a black base.
Polycystic Ovary Syndrome: Update on the Pros and Cons of Treatment Options
March 1st 2007ABSTRACT: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among females of reproductive age. In adolescents, PCOS often manifests with irregular menses, hirsutism, and acne. Despite general agreement that the metabolic derangements of PCOS arise during puberty, the condition is diagnosed more often in adults than in adolescents. Treatment is focused on weight loss, menstrual cycle regulation, and amelioration of physical symptoms. Acute symptoms can be managed with combination oral contraceptives and antiandrogens and potentially with insulin-sensitizing drugs. Lifestyle modification, especially in overweight patients, can reduce symptoms and help prevent long-term health consequences.