April 18th 2025
The sBLA for dupilumab (Dupixent) was supported by data from the phase 3 LIBERTY-CUPID clinical program in patients with uncontrolled CSU.
A Tethered Approach to Type 2 Diabetes Care – Connecting Insulin Regimens with Digital Technology
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Surv.AI Says™: What Clinicians and Patients Are Saying About Glucose Management in the Technology Age
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Addressing Healthcare Inequities: Tailoring Cancer Screening Plans to Address Inequities in Care
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Cases and Conversations™: Applying Best Practices to Prevent Shingles in Your Practice
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Snippets of Vaccine History: Success, Failure, and Controversy
November 19th 2010Vaccination against infectious diseases has saved millions of lives. The recurrent threat of influenza pandemics and the prevalence of global HIV infections underscore the need for better-designed, more effective vaccines.
Is topical therapy the best choice for this teenaged boy’s acne?
November 17th 2010This 14-year-old boy is brought for assessment and treatment of acne by his mother who is noted to have superficial acne scars. His 17-year-old brother has required systemic isotretinoin to control his acne, and the mother wishes to avoid any systemic therapy for her other son.
A New Trend in Homemade Tattoos
November 5th 2010A 13-year-old boy from inner city Philadelphia presented with an infected “tattoo” on his right forearm. On examination, he had multiple hypopigmented scars on his extremities. When asked about the scars, the patient appeared embarrassed and stated that they were tattoos, which he created with an eraser from a pencil.
Juvenile Dermatomyositis Sine Myositis
October 12th 2010This 8-year-old girl has had swollen, red eyelids for the past 24 hours. She denies pain or pruritus. She has had no eye drainage, fever, or other systemic signs of illness. She reports some mild fatigue for the past few months but denies myalgias or decreased muscle strength.
Keratosis pilaris: Regimens for rough skin
October 7th 2010I read with interest Drs Kumar, Noronha, and Leung's recent "What's Your Diagnosis?" case highlighting the common skin problem, keratosis pilaris. In my suburban pediatric practice, patients frequently ask me how to eradicate this benign but annoying condition.
Would you biopsy the pigmented lesion on this young boy’s thigh?
October 7th 2010This pigmented lesion has developed over the past 12 months on the posterior aspect of a 3-year-old boy's thigh. The lesion measures 5 mm and exhibits a dark black nodular center with a light brown pigmented periphery. The lesion is asymptomatic, and the child is well.
Fetal Alcohol Spectrum Disorder: How to Recognize the Various Manifestations
October 7th 2010Identification of this disorder can be difficult because of the wide range of effects of prenatal alcohol exposure. Here: tips on how to recognize its clinical manifestations and neurodevelopmental features and behaviors.
Infant With Recurrent Omphalitis and Otitis
October 7th 2010A baby boy, aged 14 days, presented with a temperature of 38.2°C (100.8°F), a generalized maculopapular rash, and purulent otorrhea. He was treated with oral amoxicillin for 10 days. At age 25 days, he again presented-this time with erythema and edema of the umbilicus, thrush, and fever of 24 hours’ duration.
Hypopigmentation Secondary to Eczema
September 13th 2010The areas of hypopigmentation on this 4-month-old girl are sequelae of eczema. The rash had developed on the infant’s upper extremities in the bilateral antecubital and popliteal fossae at 1 month of age. Her cheeks were also affected, although only slightly. Her initial diet consisted of regular infant formula. This was switched to soy formula, which she vomited. She was then given a lactose-free formula, which she tolerated well.
Infant With Multiple Birthmarks and Hypertrophic Left Arm
September 13th 2010Three-month-old boy with multiple birthmarks and hypertrophic left arm. Infant was born at 38 weeks’ gestation to a 33-year-old gravida 2, para 1 after an uncomplicated pregnancy and normal spontaneous vaginal delivery. Birth weight, 3.45 kg; length, 53 cm. Both parents healthy, nonconsanguineous. No family history of growth abnormalities. Father had port-wine stains on nape and chest.
Eczema Herpeticum With MRSA Superinfection
September 13th 2010A 7-month-old boy with a history of severe atopic dermatitis and asthma was brought for evaluation of a generalized rash, fever, and irritability of 2 days’ duration. He had no respiratory symptoms. His medical history was significant for anorexia, without vomiting or diarrhea. He had a strong family history of allergy.
Do These Multiple Asymptomatic Lesions on a Boy’s Chest Require Treatment?
September 9th 2010The lesions on this 10-year-old boy had developed during the past year. They were asymptomatic and appeared only on the anterior chest. The child's older brother had had similar lesions, also on the chest, for more than 10 years. The boys' mother was concerned that her younger son might experience the same "disfigurement" as her older son and wanted to prevent that from happening.
Atopic Dermatitis Superinfection Caused by Staphylococcus sciuri and Enterobacter asburiae
August 9th 2010The rash on this 4-week-old girl had appeared 5 days earlier on her face as thickened scales on an erythematous base and subsequently spread to the scalp, shoulder, chest, abdomen, and extremities. A few bullae were noted on the neck and hands. Initial treatment with cephalexin failed to control the rash, and the infant was admitted to the hospital for further evaluation.
Henoch-Schönlein purpura with gastric wall thickening
August 9th 2010For 3 days, a 7-year-old girl had severe, generalized abdominal pain. The patient described the pain as sharp and achy without radiation; she denied any relieving or aggravating factors. She also reported decreased appetite and energy for the past week.