April 18th 2025
The sBLA for dupilumab (Dupixent) was supported by data from the phase 3 LIBERTY-CUPID clinical program in patients with uncontrolled CSU.
A Tethered Approach to Type 2 Diabetes Care – Connecting Insulin Regimens with Digital Technology
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Surv.AI Says™: What Clinicians and Patients Are Saying About Glucose Management in the Technology Age
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Addressing Healthcare Inequities: Tailoring Cancer Screening Plans to Address Inequities in Care
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Cases and Conversations™: Applying Best Practices to Prevent Shingles in Your Practice
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Genetic Disorders: Toddler With Skeletal, Ocular, and Cardiac Anomalies
January 1st 2006A 15-month-old girl presents for evaluation of macrocephaly and unusual facial features. Her prenatal and natal history are unremarkable. The child is now developing normally after mild gross motor delays during the first 6 months of life. Mild scoliosis was noted on a babygram taken at 8 months during an evaluation for possible nonaccidental trauma.
A 9-Year-Old Girl With Eruptions and Malaise
January 1st 2006A 9-year-old girl presented with these lesions on her face and extremities. The lesions, which had developed within the past 24 hours, were warm to the touch and only mildly pruritic. The child feels unwell with nonspecific complaints of malaise and lack of energy. Before this eruption, she had been healthy and had not been taking any medications.
A hairy predicament: "Why is my toddler going bald?"
December 1st 2005The mother of a 3-year-old boy has brought him to the clinic for you to evaluate thinning of his scalp hair over the past month. She reports that the hair loss is occurring "all over" his scalp and that she has not noticed him scratching his scalp or pulling his hair. He was hospitalized four months ago for a rotavirus infection.
What’s Wrong With This Picture? Child With Fever and Persistent Cough
December 1st 2005A2¹⁄₂-year-old child is hospitalized with a 1-monthhistory of worsening persistent cough. She was initiallytreated with a 5-day course of oral amoxicillin, andher symptoms abated somewhat. However, for the pastweek, she has experienced high fever (temperatures upto 38.3°C [101°F]) and chills associated with right-sidedpleuritic chest pain.
Just plain bad news confirmed: The childhood melanoma rate is rising
November 4th 2005The rate of melanoma among children and young adults rose dramatically between 1973 and 2001, according to a study in a recent issue of the Journal of Clinical Oncology. "Between the years 1973 and 2001, the incidence of pediatric melanoma increased 2.9% per year and 46% per year of age," says John Strouse, MD, a pediatric oncologist and instructor in pediatrics at the Johns Hopkins University and author of the article.
Allergic conditions exact a heavy toll, says specialist
October 11th 2005Allergic diseases are the sixth leading cause of chronic disease in the United States and cost the health-care system more than $18 billion a year. But despite the seriousness suggested by these numbers, many people don't understand how deflating allergies can be to quality of life for patients and families, according to Mark Boguniewicz, MD, professor at Denver's National Jewish Medical and Research Center.
Cold Injuries: A Guide to Preventing--and Treating--Hypothermia and Frostbite
October 1st 2005ABSTRACT: Hypothermia is not limited to the northern states: people also die of hypothermia in other areas with milder climates. Infants, young adolescent boys, and inadequately dressed teens who abuse alcohol or illicit drugs are at highest risk for death secondary to hypothermia. The mildly hypothermic patient may appear fatigued and display persistent shivering, ataxia, clumsiness, confusion, tachypnea, and tachycardia. The child with moderate hypothermia will not be shivering; declining mental status may cause the freezing patient to remove clothing. An irregular heartbeat is likely at this stage. Severe hypothermia is marked by apnea, stupor, and coma. In a frostbitten patient, rapid rewarming of the affected area in warm water for 15 to 30 minutes is the first step. Potent analgesia is often necessary. After thawing, the frostbitten part is kept dry, warm, and loosely covered. With an adequate dose of common sense, the vast majority of deaths from cold injury can be prevented.
Case In Point: Eczema Herpeticum: An Uncommon Complication of Atopic Dermatitis
October 1st 2005A 2-year-old boy was brought for evaluation of a rash and fever of 2 days' duration. He had atopic dermatitis since 6 months of age that was partially controlled with low-potency topical corticosteroids and emollients. His father reported that recently the facial dermatitis had worsened, with increased redness, pain, and some skin breakdown. The child's medical history was otherwise unremarkable. His mother had a history of "cold sores."
PEDIATRICS UPDATE: Infectious Risk for Children in the Wake of Katrina
October 1st 2005In the aftermath of Hurricane Katrina's devastation in the Gulf Coast region, it is important for physicians in the United States to consider the infectious disease risks for children who have been displaced or who are still living in affected areas. These risks include infections acquired through ingestion of waterborne organisms; wound infections; lack of immunization continuity; and overcrowding, which increases the risk of respiratory or GI infections. In addition, problems will arise from disruption of therapy for select populations of children, such as those who are HIV-infected; those receiving immunosuppressive treatment; and those in need of continuous antibiotic prophylaxis, such as those who have sickle cell disease.
An Adolescent Girl With Painful Purple Papules
October 1st 2005This adolescent girl presents with painful purple papules that have developed on her toes. These papules are making it impossible for her to wear her "fashion" shoes to school in the late fall and early winter. She reports that her feet have been cold for as long as she can remember and that she is not bothered by it. She is otherwise healthy, takes no medications, and does not smoke.
Papular lesions and thickened nails on the feet: A "Don't Walk" sign?
September 1st 2005Your patient is a 14-year-old boy who complains of bilateral foot pain of several weeks' duration. Sometimes, he tells you, the pain is so bad that he cannot bear weight and has to crawl from place to place. As you talk with him, you note that all 10 fingernails are abnormally thick and raised.
Acne is a pox on big moments in teenage girls' lives, poll shows
September 1st 2005In a recent survey by the American Counseling Association (ACA), eight in 10 adolescent girls said that acne makes them feel embarrassed, unhappy, or less attractive. The survey, underwritten by Dermik Laboratories, polled 738 girls between 13 and 17 years old. Its goal was to raise public awareness of the impact of acne during important moments in a teenager's life.
ID Q & A: Answers to Infectious Disease Questions Treating Spider Bites: Is Dapsone an Option?
September 1st 2005Some studies suggest that orally administered dapsone is effective for infections caused by spider bites (eg, brown recluse spiders) in dosages of 4 mg/kg/d for 3 days. Can dapsone be used in children and, if so, at what dosage?
Consultations & Comments: Try a Little Balsamic With That Seawater?
September 1st 2005While spending a month in Cuba, my travel companion experienced seabather's eruption (Figure), which was described by Drs Mary Sy and Gary Williams in their Photo Essay "The Dermatologic Perils of Swimming" (CONSULTANT FOR PEDIATRICIANS, July/August 2004, page 333). Fortunately, some Cuban onlookers knew how to treat this condition (referred to locally as "El Caribe"). After vinegar was applied to the eruption, the pruritus and burning diminished almost immediately.